| Identification | Back Directory | [Name]
Jagged-1 (188-204) | [CAS]
219127-21-6 | [Synonyms]
Jagged-1 (188-204)
L-Arginine, L-cysteinyl-L-α-aspartyl-L-α-aspartyl-L-tyrosyl-L-tyrosyl-L-tyrosylglycyl-L-phenylalanylglycyl-L-cysteinyl-L-asparaginyl-L-lysyl-L-phenylalanyl-L-cysteinyl-L-arginyl-L-prolyl- | [Molecular Formula]
C93H127N25O26S3 | [MDL Number]
MFCD09750584 | [MOL File]
219127-21-6.mol | [Molecular Weight]
2107.37 |
| Chemical Properties | Back Directory | [density ]
1.53±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [Sequence]
Cys-Asp-Asp-Tyr-Tyr-Tyr-Gly-Phe-Gly-Cys-Asn-Lys-Phe-Cys-Arg-Pro-Arg |
| Hazard Information | Back Directory | [Uses]
Jagged-1 (188-204) is a fragment of the Jagged-1 (JAG-1) protein with Notch agonist activity. JAG-1 is a Notch ligand highly expressed in cultured and primary multiple myeloma (MM) cells. JAG-1 induces maturation of monocyte-derived human dendritic cells[1][2][3]. | [References]
[1] Jundt F, et al. Jagged1-induced Notch signaling drives proliferation of multiple myeloma cells. Blood. 2004 May 1;103(9):3511-5. DOI:10.1182/blood-2003-07-2254
[2] Weijzen S, et al. The Notch ligand Jagged-1 is able to induce maturation of monocyte-derived human dendriticcells. J Immunol. 2002 Oct 15;169(8):4273-8. DOI:10.4049/jimmunol.169.8.4273
[3] Nickoloff BJ, et al. Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-kappaB and PPARgamma. Cell Death Differ. 2002 Aug;9(8):842-55. DOI:10.1038/sj.cdd.4401036 |
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