| Identification | Back Directory | [Name]
7,3',4'-TRIHYDROXYFLAVANONE | [CAS]
21913-99-5 | [Synonyms]
BUTIN
3',4',7-trihydroxyflavanone
7,3',4'-TRIHYDROXYFLAVANONE | [Molecular Formula]
C15H12O5 | [MDL Number]
MFCD00017739 | [MOL File]
21913-99-5.mol | [Molecular Weight]
272.25 |
| Chemical Properties | Back Directory | [Boiling point ]
582.4±50.0 °C(Predicted) | [density ]
1.485±0.06 g/cm3(Predicted) | [solubility ]
Acetonitrile: Soluble
Methanol: Soluble | [form ]
Solid | [pka]
7.69±0.40(Predicted) | [color ]
Light yellow to light brown |
| Hazard Information | Back Directory | [Uses]
Butin is a major biologically active flavonoid isolated from the heartwood of Dalbergia odorifera with oral activity, with strong antioxidant, antiplatelet and anti-inflammatory activities. Butin significantly alleviates myocardial infarction and improves heart function, together with prevents diabetes-induced cardiac oxidative damage in rat[1][2]. | [Definition]
ChEBI: 2-(3,4-dihydroxyphenyl)-7-hydroxy-3,4-dihydro-2H-1-benzopyran-4-one is a member of flavanones. | [in vivo]
Butin (10-40 mg/kg, orally, twice a day, 15 days) can significantly reduce myocardial ischemia-reperfusion injury in diabetic mice, improve heart function, and increase the ability to resist oxidative stress[1].
Butin (25-50 mg/kg, intraperitoneal injection, single dose) can reduce behavioral changes and neuronal conditions in rats with cerebral hemorrhage by reducing apoptosis and inflammatory responses[2]. | Animal Model: | C57/BL6J mice induced by STZ(HY-13753)[1] | | Dosage: | 10, 20, 40 mg/kg; twice a day; 15 days | | Administration: | Oral | | Result: | Improved cardiac function, significant increases in LVSP, +dP/dtmax and -dP/dtmin, reduced myocardial infarction area, reduced caspase-3 activity and Bax/Bcl-2 ratio, reduced GSH-px, GSH, SOD, CAT and GR activity. |
| Animal Model: | Intracerebral hemorrhage rats[2] | | Dosage: | 25, 50 mg/kg; single dose | | Administration: | Intraperitoneal injection (i.p.) | | Result: | Increased the neurological score, significantly reduced the volume of hemorrhagic lesions, significantly reduced the Bax/Bcl-2 ratio and caspase-3 protein expression, and significantly reduced brain tissue inflammatory mediators tumor necrosis factor-α (TNF-α) and interleukin. Reduced levels of 6 (IL-6). |
| [References]
[1] Duan J, et al. Protective effect of butin against ischemia/reperfusion-induced myocardial injury in diabetic mice: involvement of the AMPK/GSK-3β/Nrf2 signaling pathway. Sci Rep. 2017 Jan 27;7:41491. DOI:10.1038/srep41491
[2] Li P, et al. Butin Attenuates Brain Edema in a Rat Model of Intracerebral Hemorrhage by Anti Inflammatory Pathway. Transl Neurosci. 2018 May 8;9:7-12. DOI:10.1515/tnsci-2018-0002 |
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