| Identification | Back Directory | [Name]
2-Propen-1-one, 1-[(2S,5R)-2-methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-, 4-methylbenzenesulfonate (1:1) | [CAS]
2192215-81-7 | [Synonyms]
Ritlecitinib tosylate
2-Propen-1-one, 1-[(2S,5R)-2-methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-, 4-methylbenzenesulfonate (1:1) | [EINECS(EC#)]
201-058-9 | [Molecular Formula]
C22H27N5O4S | [MOL File]
2192215-81-7.mol | [Molecular Weight]
457.55 |
| Chemical Properties | Back Directory | [form ]
Solid | [color ]
White to off-white | [InChIKey]
YOZLVAFWYLSRRN-NFGOAHBONA-N | [SMILES]
S(C1C=CC(C)=CC=1)(O)(=O)=O.N([C@@H]1CC[C@H](C)N(C(=O)C=C)C1)C1N=CN=C2NC=CC=12 |&1:12,15,r| |
| Hazard Information | Back Directory | [Uses]
Ritlecitinib tosylate is an orally active and selective JAK3 inhibitor with an IC50 of 33.1 nM. Ritlecitinib tosylate is used for inflammatory and autoimmune diseases research[1]. | [References]
[1] Telliez JB, et al. Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective Inhibition. ACS Chem Biol. 2016 Dec 16;11(12):3442-3451. DOI:10.1021/acschembio.6b00677 |
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