| Identification | Back Directory | [Name]
9,10-Anthracenedione, 2-hydroxy-1,7,8-trimethoxy-3-methyl- | [CAS]
2195434-05-8 | [Synonyms]
2-Hydroxy-1,7,8-trimethoxy-3-methyl-9,10-anthracenedione
9,10-Anthracenedione, 2-hydroxy-1,7,8-trimethoxy-3-methyl- | [Molecular Formula]
C18H16O6 | [MOL File]
2195434-05-8.mol | [Molecular Weight]
328.32 |
| Hazard Information | Back Directory | [Uses]
OAT1/3-IN-2 (compound 8) is a dual inhibitor of OAT1 and OAT3. OAT1/3-IN-2 can reverse the toxicity of Cys-Hg on HEK-OAT1 cells (10 μM) and has a potential protective effect on the kidneys. OAT1/3-IN-2 can be used to study mercury-induced kidney damage[1]. | [References]
[1] Wang X, et al. From the Cover: Identification of Natural Products as Inhibitors of Human Organic Anion Transporters (OAT1 and OAT3) and Their Protective Effect on Mercury-Induced Toxicity. Toxicol Sci. 2018 Feb 1;161(2):321-334. DOI:10.1093/toxsci/kfx216
[2] Wang X. et al. From the Cover: Identification of Natural Products as Inhibitors of Human Organic Anion Transporters (OAT1 and OAT3) and Their Protective Effect on Mercury-Induced Toxicity. Toxicol Sci. 2018 Feb 1;161(2):321-334. DOI:10.1093/toxsci/kfx216 |
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