| Chemical Properties | Back Directory | [density ]
1.236±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
DMSO : 150 mg/mL (585.25 mM) | [form ]
Solid | [pka]
9.04±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
TH34, an HDAC6/8/10 inhibitor with IC50s of 4.6 μM, 1.9 μM, and 7.7 μM respectively, shows high selectivity over HDAC1/2/3[1]. | [Biological Activity]
TH34 is an HDAC6/8/10 inhibitor with IC50 values of 4.6 μM, 1.9 μM and 7.7 μM, respectively, showing high selectivity compared with HDAC1/2/3. | [in vitro]
TH34 induces caspase-dependent programmed cell death and cell cycle arrest in neuroblastoma cells. | [target]
| HDAC6 4.6 μM (IC 50 ) | HDAC8 1.9 μM (IC 50 ) | HDAC10 7.7 μM (IC 50 ) | | [IC 50]
HDAC6: 4.6 μM (IC50); HDAC8: 1.9 μM (IC50); HDAC10: 7.7 μM (IC50) | [References]
[1] Kolbinger FR, et al. The HDAC6/8/10 inhibitor TH34 induces DNA damage-mediated cell death in human high-grade neuroblastoma cell lines. Arch Toxicol. 2018 Aug;92(8):2649-2664. DOI:10.1007/s00204-018-2234-8 |
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| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
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