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2196203-96-8

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2196203-96-8 Structure

2196203-96-8 Structure
IdentificationBack Directory
[Name]

TH34
[CAS]

2196203-96-8
[Synonyms]

TH34
CS-2858
TH34;TH 34
[Molecular Formula]

C15H16N2O2
[MDL Number]

MFCD31812450
[MOL File]

2196203-96-8.mol
[Molecular Weight]

256.3
Chemical PropertiesBack Directory
[density ]

1.236±0.06 g/cm3(Predicted)
[storage temp. ]

Keep in dark place,Inert atmosphere,Room temperature
[solubility ]

DMSO : 150 mg/mL (585.25 mM)
[form ]

Solid
[pka]

9.04±0.10(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

TH34, an HDAC6/8/10 inhibitor with IC50s of 4.6 μM, 1.9 μM, and 7.7 μM respectively, shows high selectivity over HDAC1/2/3[1].
[Biological Activity]

TH34 is an HDAC6/8/10 inhibitor with IC50 values of 4.6 μM, 1.9 μM and 7.7 μM, respectively, showing high selectivity compared with HDAC1/2/3.
[in vitro]

TH34 induces caspase-dependent programmed cell death and cell cycle arrest in neuroblastoma cells.

[target]

HDAC6

4.6 μM (IC 50 )

HDAC8

1.9 μM (IC 50 )

HDAC10

7.7 μM (IC 50 )

[IC 50]

HDAC6: 4.6 μM (IC50); HDAC8: 1.9 μM (IC50); HDAC10: 7.7 μM (IC50)
[References]

[1] Kolbinger FR, et al. The HDAC6/8/10 inhibitor TH34 induces DNA damage-mediated cell death in human high-grade neuroblastoma cell lines. Arch Toxicol. 2018 Aug;92(8):2649-2664. DOI:10.1007/s00204-018-2234-8
Spectrum DetailBack Directory
[Spectrum Detail]

TH34(2196203-96-8)1HNMR
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