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219655-57-9

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219655-57-9 Structure

219655-57-9 Structure
IdentificationBack Directory
[Name]

GUANIDINYL NALTRINDOLE
[CAS]

219655-57-9
[Synonyms]

5'guanidinonaltrindole bis(trifluoroacetate)
5'-Guanidinonaltrindole di(trifluoroacetate)
5′-Guanidinonaltrindole di(trifluoroacetate) salt hydrate
5μ-Guanidinonaltrindole hydrate di(trifluoroacetate) salt
[Molecular Formula]

C27H29N5O3
[MDL Number]

MFCD03788471
[MOL File]

219655-57-9.mol
[Molecular Weight]

471.558
Chemical PropertiesBack Directory
[storage temp. ]

2-8°C
[solubility ]

H2O: soluble30mg/mL
[form ]

solid
[Water Solubility ]

H2O: 30mg/mL
Safety DataBack Directory
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

5′-Guanidinonaltrindole di(trifluoroacetate) salt hydrate (GNTI) has been used as a selective κ opioid receptor antagonist:
  • to study the influence of opioid receptor types on the anti-hyperalgesic effect of dipeptidyl peptidase 4 (DPP4) inhibitors in inflammation
  • to study the role of κ opioid receptor in the forebrain-dependent associative task, Whisker-Trace Eyeblink conditioning (WTEB)
  • to validate its inhibitory actions on Akt kinase activities

[Uses]

5′-Guanidinonaltrindole di(trifluoroacetate) Salt is a selective opioid receptor antagonist. It has also been utilized to develop fluorescent methods to identify phosphopantetheinyl transferase inhibitors.
[Biochem/physiol Actions]

5′-Guanidinonaltrindole di(trifluoroacetate) (GNTI) is a 5‘-guanidine derivative and a selective κ opiate receptor antagonist. It is five-fold more potent and 500-fold more selective than norbinaltorphimine (nor-BNI) for the κ opioid receptor in smooth muscle preparations.
219655-57-9 suppliers list
Company Name: TargetMol Chemicals Inc.  
Telephone: 15002134094
Website: https://www.targetmol.cn/
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