| Identification | Back Directory | [Name]
2,5-Dibromo-4-methylimidazole | [CAS]
219814-29-6 | [Synonyms]
2,5-DIBROMO-4-METHYLIMIDAZOLE
2,5-Dibromo-4-methyl-1H-imidazole
2,4-dibromo-5-methyl-1H-imidazole
1H-Imidazole, 2,5-dibromo-4-methyl-
1H-Imidazole, 2,4-dibromo-5-methyl- | [Molecular Formula]
C4H4Br2N2 | [MDL Number]
MFCD02179519 | [MOL File]
219814-29-6.mol | [Molecular Weight]
239.9 |
| Chemical Properties | Back Directory | [Boiling point ]
343.1±34.0 °C(Predicted) | [density ]
2.188±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [pka]
9.47±0.10(Predicted) | [Appearance]
Off-white to light yellow Solid |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 2,5-dibromo-4-methylimidazole from 4-methylimidazole: 4-methylimidazole (3.4 g, 40 mmol) was dissolved in tetrahydrofuran (THF, 50 mL) at room temperature. Subsequently, N-bromosuccinimide (NBS, 14 g, 80 mmol) was added to this solution. The reaction mixture was stirred for 1 hour. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The crude product was purified by silica gel column chromatography (eluent ratio: petroleum ether (PE):ethyl acetate (EA) = 2:1) to afford 2,5-dibromo-4-methylimidazole (9.6 g, 99% yield) as a white solid. Mass spectrometry (ESI-MS) analysis showed: m/z 239.0 [M + H]+. | [References]
[1] Patent: WO2015/26792, 2015, A1. Location in patent: Paragraph 0229 |
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| Company Name: |
Tetranov Biopharm
|
| Tel: |
13526569071 |
| Website: |
http://www.leadmedpharm.com/index.html |
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