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219920-81-7

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219920-81-7 Structure

219920-81-7 Structure

Identification	Back Directory
[Name] Bisnorcymserine
[CAS] 219920-81-7
[Synonyms] Bisnorcymserine N1N8Bisnorcymserine N1-N8-Bisnorcymserine N1 N8 Bisnorcymserine Carbamic acid, N-[4-(1-methylethyl)phenyl]-, (3aS,8aR)-1,2,3,3a,8,8a-hexahydro-3a-methylpyrrolo[2,3-b]indol-5-yl ester
[Molecular Formula] C21H25N3O2
[MOL File] 219920-81-7.mol
[Molecular Weight] 351.44

Chemical Properties	Back Directory
[Boiling point ] 491.2±45.0 °C(Predicted)
[density ] 1.192±0.06 g/cm3(Predicted)
[pka] 13.02±0.70(Predicted)

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[Uses] Bisnorcymserine ((-)-Bisnorcymserine) is an inhibitor for butyrylcholinesterase (BChE) with an IC50 of 0.228 nM. Bisnorcymserine reduces the levels of amyloid-β peptide (Aβ), exhibits ameliorates the Alzheimer’s Disease in elderly rat models. Bisnorcymserine is blood-brain barrier penetrate[1].
[IC 50] BChE: 0.228 nM (IC₅₀)
[References] [1] Kamal MA, et al., Kinetics of human serum butyrylcholinesterase and its inhibition by a novel experimental Alzheimer therapeutic, bisnorcymserine. J Alzheimers Dis. 2006 Sep;10(1):43-51. DOI:10.3233/jad-2006-10108

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Company Name:	TargetMol Chemicals Inc.
Tel:	+1-781-999-5354; +17819995354 , +17819995354
Website:	https://www.targetmol.com/

Company Name:	TargetMol Chemicals Inc.
Tel:	+17819995354 , +17819995354
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Company Name:	TargetMol Chemicals Inc.
Tel:	15002134094
Website:	https://www.targetmol.cn/

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