| Identification | Back Directory | [Name]
2-Thiophenecarboxylic acid, 5-chloro-3-pyridinyl ester | [CAS]
219929-01-8 | [Synonyms]
2-Thiophenecarboxylic acid, 5-chloro-3-pyridinyl ester | [Molecular Formula]
C10H6ClNO2S | [MOL File]
219929-01-8.mol | [Molecular Weight]
239.68 |
| Hazard Information | Back Directory | [Description]
MAC-5576 a SARS-CoV-2 Protease inhibitor (IC50 = 81 nM). | [Uses]
MAC-5576 is a SARS-CoV-2 3CL protease inhibitor, with an IC50 of 81 nM. MAC-5576 also inhibits 3CLpro (IC50=0.5 μM), HAV 3Cpro (IC50=0.5 μM), and thrombin (IC50=13 μM)[1][2]. | [References]
[1] Jan E Blanchard, et al. High-throughput screening identifies inhibitors of the SARS coronavirus main proteinase. Chem Biol. 2004 Oct;11(10):1445-53. DOI:10.1016/j.chembiol.2004.08.011
[2] Sho Iketani, et al. Lead compounds for the development of SARS-CoV-2 3CL protease inhibitors. Nat Commun. 2021 Apr 1;12(1):2016. DOI:10.1038/s41467-021-22362-2 |
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