| Identification | Back Directory | [Name]
AR-A 2 | [CAS]
220051-79-6 | [Synonyms]
AR-A 2
AR-A 000002
Benzamide, 4-(4-morpholinyl)-N-[(2R)-1,2,3,4-tetrahydro-5-methyl-8-(4-methyl-1-piperazinyl)-2-naphthalenyl]- | [Molecular Formula]
C27H36N4O2 | [MDL Number]
MFCD08056230 | [MOL File]
220051-79-6.mol | [Molecular Weight]
448.6 |
| Chemical Properties | Back Directory | [Boiling point ]
697.1±55.0 °C(Predicted) | [density ]
1.22±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
15.50±0.20(Predicted) |
| Hazard Information | Back Directory | [Uses]
AR-A 2 is a selective 5-HT1B receptor antagonist, with high affinity to guinea pig cortex 5HT1B/1D and recombinant guinea pig 5-HT1B receptors (Ki=0.24 and 0.47 nM) and with 10-fold lower affinity to guinea pig 5-HT1D receptor (Ki, 5 nM), and shows an EC50 of 4.5 nM for the guinea pig 5-HT1B receptor; AR-A 2 can be used in the research of depression and anxiety. | [IC 50]
5-HT1B/D Receptor: 20 nM (Ki); 5-HT2A Receptor: 339 nM (Ki); 5-HT1A Receptor: 3070 nM (Ki) | [storage]
Store at -20°C | [References]
[1] Ahlgren C, et al. In vitro characterization of AR-A000002, a novel 5-hydroxytryptamine(1B) autoreceptor antagonist. Eur J Pharmacol. 2004 Sep 19;499(1-2):67-75. DOI:10.1016/j.ejphar.2004.07.067 |
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