| Identification | Back Directory | [Name]
KF31327 | [CAS]
220060-39-9 | [Synonyms]
KF31327
Thioquinapiperifil
3-ethyl-8-[[2-[4-(hydroxymethyl)piperidin-1-yl]phenyl]methylamino]-1H-imidazo[4,5-g]quinazoline-2-thione
2H-Imidazo[4,5-g]quinazoline-2-thione, 3-ethyl-1,3-dihydro-8-[[[2-[4-(hydroxymethyl)-1-piperidinyl]phenyl]methyl]amino]- | [Molecular Formula]
C24H28N6OS | [MDL Number]
MFCD11977835 | [MOL File]
220060-39-9.mol | [Molecular Weight]
448.58 |
| Hazard Information | Back Directory | [Uses]
Thioquinapiperifil (KF31327 free base), a potent, selective and non-competitive phosphodiesterase-5 (PDE-5, IC50 of 0.074 nM) inhibitor, is used for sexual enhancement study[1][2]. | [Biological Activity]
Thioquinapiperifil (KF31327 free base) is a potent, selective, and noncompetitive inhibitor of phosphodiesterase (PDE-5) (IC50 of 0.074 nM) for sexual maturation studies. | [in vitro]
Thioquinapiperifil can be found in dietary supplements. Thioquinapiperifil (KF31327 free base) (0.1-10 μM) concentration dependently inhibits platelet aggregation. In the absence of nitroglycerin, higher concentrations 1 and 10 μM of Thioquinapiperifil (KF31327 free base) are required to inhibit platelet aggregation. | [target]
| PDE5 0.074 nM (IC 50 ) | PDE1 380 nM (IC 50 ) | PDE2 670 nM (IC 50 ) | PDE3 38 nM ( IC 50 ) | PDE4 800 nM (IC 50 ) | | [IC 50]
PDE5: 0.074 nM (IC50); PDE1: 380 nM (IC50); PDE2: 670 nM (IC50); PDE3: 38 nM (IC50); PDE4: 800 nM (IC50) | [References]
[1] Nahoko Uchiyama, et al. Determination of a new type of phosphodiesterase-5 inhibitor, thioquinapiperifil, in a dietary supplement promoted for sexual enhancement. Chem Pharm Bull (Tokyo). 2008 Sep;56(9):1331-4. DOI:10.1248/cpb.56.1331
[2] R Hirose, et al. KF31327, a new potent and selective inhibitor of cyclic nucleotide phosphodiesterase 5. Eur J Pharmacol. 2001 Nov 9;431(1):17-24. DOI:10.1016/s0014-2999(01)01422-4 |
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| Company Name: |
BOC Sciences
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16314854226 |
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www.bocsci.com |
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MedChemExpress
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