| Chemical Properties | Back Directory | [Boiling point ]
512.380±60.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.328±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [solubility ]
DMSO: 2 mg/mL, clear | [form ]
Solid | [pka]
3.180±0.31(predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
I-BET787 is a pan-BET bromine domain inhibitor with oral activity. I-BET787 shows effectiveness in a mouse model of inflammation[1]. | [References]
[1] Hirst DJ, et al. Structure- and Property-Based Optimization of Efficient Pan-Bromodomain and Extra Terminal Inhibitors to Identify Oral and Intravenous Candidate I-BET787. J Med Chem. 2024 Jun 27;67(12):10464-10489. DOI:10.1021/acs.jmedchem.4c00959 |
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