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I-BET787 is a pan-BET bromine domain inhibitor with oral activity. I-BET787 shows effectiveness in a mouse model of inflammation[1]. | [References]
[1] Hirst DJ, et al. Structure- and Property-Based Optimization of Efficient Pan-Bromodomain and Extra Terminal Inhibitors to Identify Oral and Intravenous Candidate I-BET787. J Med Chem. 2024 Jun 27;67(12):10464-10489. DOI:10.1021/acs.jmedchem.4c00959 |
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