| Identification | Back Directory | [Name]
7-Indolizinecarboxamide, N-[(1,2-dihydro-4-methoxy-6-methyl-2-oxo-3-pyridinyl)methyl]-6-methyl-1-(6-methyl-3-pyridazinyl)-5-[(1S)-1-[4-(2,2,2-trifluoroethyl)-1-piperazinyl]ethyl]- | [CAS]
2202678-05-3 | [Synonyms]
(S)-HH2853
7-Indolizinecarboxamide, N-[(1,2-dihydro-4-methoxy-6-methyl-2-oxo-3-pyridinyl)methyl]-6-methyl-1-(6-methyl-3-pyridazinyl)-5-[(1S)-1-[4-(2,2,2-trifluoroethyl)-1-piperazinyl]ethyl]- | [Molecular Formula]
C31H36F3N7O3 | [MOL File]
2202678-05-3.mol | [Molecular Weight]
611.66 |
| Hazard Information | Back Directory | [Uses]
(S)-HH2853 (compound 200), a PYRIDINO five membered aromatic ring compound, is a potent EZH1/2 dual inhibitor with an IC50 of <100 nM for EZH2_Y641F. (S)-HH2853 has the potential to be used in the research of anti-tumor or autoimmune diseases[1]. | [IC 50]
EZH1; EZH2 Y641N: <100 nM (IC50) | [References]
[1] Xuxing Chen, et al. PYRIDINO five membered aromatic ring compounds, preparation method and application thereof. WO2018045971A1. |
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