| Chemical Properties | Back Directory | [Boiling point ]
1469.3±65.0 °C(Predicted) | [density ]
1.409±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
4.44±0.10(Predicted) | [color ]
White to off-white | [Sequence]
Ac-Lys-Pro-Ser-Ser-Pro-Pro-Glu-Glu-NH2 |
| Hazard Information | Back Directory | [Uses]
Angstrom6 (A6 Peptide) is an 8 amino-acid peptide derived from single-chain urokinase plasminogen activator (scuPA) and interferes with the uPA/uPAR cascade and abrogates downstream effects. Angstrom6 binds to CD44 resulting in the inhibition of migration, invasion, and metastasis of tumor cells, and the modulation of CD44-mediated cell signaling[1][2]. | [in vivo]
Angstrom6 (100 mg/kg; s.c. twice daily) reduces the number of lung foci generated by the i.v. injection of B16-F10 melanoma cells by 50%[3]. | Animal Model: | C57Bl/6 mice (bearing B16-F10 cells)[3] | | Dosage: | 100 mg/kg | | Administration: | S.c.; twice a day for 11 days | | Result: | Reduced the number of lung nodules and reduced the number of lung metastases to 50% of control.
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Store at -20°C | [References]
[1] Ghamande SA, et al. A phase 2, randomized, double-blind, placebo-controlled trial of clinical activity and safety of subcutaneous A6 in women with asymptomatic CA125 progression after first-line chemotherapy of epithelial ovarian cancer. Gynecol Oncol. 2008;111(1):89-94. DOI:10.1016/j.ygyno.2008.06.028
[2] Finlayson M. Modulation of CD44 Activity by A6-Peptide. Front Immunol. 2015;6:135. Published 2015 Mar 30. DOI:10.3389/fimmu.2015.00135
[3] Piotrowicz RS, et al. A6 peptide activates CD44 adhesive activity, induces FAK and MEK phosphorylation, and inhibits the migration and metastasis of CD44-expressing cells. Mol Cancer Ther. 2011;10(11):2072-2082. DOI:10.1158/1535-7163.MCT-11-0351 |
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