| Identification | Back Directory | [Name]
Mal-PEG4-Glu(OH)-NH-m-PEG24 | [CAS]
2204309-09-9 | [Synonyms]
Mal-PEG4-Glu(OH)-NH-m-PEG24
MAL-dPEG??-Glu(OH)-NH-m-dPEG??? | [Molecular Formula]
C72H134N4O35 | [MDL Number]
MFCD31657173 | [MOL File]
2204309-09-9.mol | [Molecular Weight]
1615.84 |
| Hazard Information | Back Directory | [Uses]
Mal-PEG4-Glu(OH)-NH-m-PEG24 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [Biological Activity]
Mal-PEG4-Glu(OH)-NH-m-PEG24 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [IC 50]
PEGs | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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