| Identification | Back Directory | [Name]
2,6-Piperidinedione, 3-(1,3-dihydro-4-iodo-1-oxo-2H-isoindol-2-yl)- | [CAS]
2207541-30-6 | [Synonyms]
Lenalidomide-I
3-(4-iodo-1-oxoisoindolin-2-yl)piperidine-2,6-dione
2,6-Piperidinedione, 3-(1,3-dihydro-4-iodo-1-oxo-2H-isoindol-2-yl)- | [Molecular Formula]
C13H11IN2O3 | [MOL File]
2207541-30-6.mol | [Molecular Weight]
370.14 |
| Chemical Properties | Back Directory | [Boiling point ]
601.2±55.0 °C(Predicted) | [density ]
1.876±0.06 g/cm3(Predicted) | [storage temp. ]
Storage temp. 2-8°C | [solubility ]
DMSO : 25 mg/mL (67.54 mM; Need ultrasonic) | [form ]
Solid | [pka]
10.67±0.40(Predicted) | [color ]
Light yellow to yellow | [InChI]
InChI=1S/C13H11IN2O3/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18/h1-3,10H,4-6H2,(H,15,17,18) | [InChIKey]
BKIUJJLYXXEGFT-UHFFFAOYSA-N | [SMILES]
N1C(=O)CCC(N2CC3=C(C2=O)C=CC=C3I)C1=O |
| Hazard Information | Back Directory | [Uses]
Lenalidomide-I (Compound 72), an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, is used in the recruitment of CRBN protein. Lenalidomide-I can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BET degrader QCA570 (HY-112609)[1]. | [Biological Activity]
Lenalidomide-I (Compound 72), an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, is used in the recruitment of CRBN protein. Lenalidomide-I can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BET degrader QCA570 [1].
Lenalidomide-I can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1]. | [IC 50]
Cereblon | [References]
[1]. Qin C, et, al. Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression. J Med Chem. 2018 Aug 9;61(15):6685-6704. |
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