| Identification | Back Directory | [Name]
11-amino- Undecanoic acid, 1,1-dimethylethyl ester | [CAS]
220851-29-6 | [Synonyms]
tert-Butyl 11-aminoundecanoate
11-amino- Undecanoic acid, 1,1-dimethylethyl ester
Undecanoic acid, 11-amino-, 1,1-dimethylethyl ester | [Molecular Formula]
C15H31NO2 | [MOL File]
220851-29-6.mol | [Molecular Weight]
257.41 |
| Chemical Properties | Back Directory | [Boiling point ]
328.9±15.0 °C(Predicted) | [density ]
0.908±0.06 g/cm3(Predicted) | [form ]
Liquid | [pka]
10.67±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Uses]
tert-Butyl 11-aminoundecanoate (compound 6b) is a PROTAC linker, which refers to the PEG composition. tert-Butyl 11-aminoundecanoate can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [IC 50]
Alkyl/ether | [References]
[1] Kim K, et al. Disordered region of cereblon is required for efficient degradation by proteolysis-targeting chimera. Sci Rep. 2019 Dec 23;9(1):19654. DOI:10.1038/s41598-019-56177-5 |
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Shanghai GL Peptide Ltd.
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+86-21-61263340; 17609490614 13764994101 |
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https://www.chemicalbook.com/supplier/10480342/ |
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