| Identification | Back Directory | [Name]
JH-VIII-49 | [CAS]
2209084-73-9 | [Synonyms]
JH-VIII-49
Androst-5-en-3-amine, 17-(7-isoquinolinyl)-N,N-dimethyl-, (3β,17β)- | [Molecular Formula]
C30H40N2 | [MOL File]
2209084-73-9.mol | [Molecular Weight]
428.66 |
| Hazard Information | Back Directory | [Uses]
JH-VIII-49 (compound 10) is a potent and selective CDK8 inhibitor (IC50=16 nM) with excellent biological activity. JH-VIII-49 promotes CDK8 inhibition through its steroid backbone design. JH-VIII-49 can be used in the synthesis of PROTAC as a target protein ligand of JH-XI-10-02 (HY-111518)[1][2]. | [IC 50]
CDK8: 16 nM (IC50) | [References]
[1] Development of Highly Potent and Selective Steroidal Inhibitors and Degraders of CDK8 |
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