| Identification | Back Directory | [Name]
1H-Pyrrole-3-methanamine, 5-(2-fluorophenyl)-1-[[3-(3-methoxypropoxy)phenyl]sulfonyl]-N-methyl-, hydrochloride (1:1) | [CAS]
2209911-80-6 | [Synonyms]
P-CAB agent 2 hydrochloride
1H-Pyrrole-3-methanamine, 5-(2-fluorophenyl)-1-[[3-(3-methoxypropoxy)phenyl]sulfonyl]-N-methyl-, hydrochloride (1:1) | [Molecular Formula]
C22H26ClFN2O4S | [MOL File]
2209911-80-6.mol | [Molecular Weight]
468.97 |
| Hazard Information | Back Directory | [Uses]
P-CAB agent 2 hydrochloride is a potent and orally active potassium-competitive acid blocker and a gastric acid secretion inhibitor. P-CAB agent 2 hydrochloride inhibits H+/K+-ATPase activity with an IC50 value of <100 nM. P-CAB agent 2 hydrochloride inhibits the hERG potassium channel with an IC50 value of 18.69 M. P-CAB agent 2 hydrochloride shows no acute toxicity and inhibits histamine (HY-B1204)-induced gastric acid secretion[1]. | [in vivo]
P-CAB agent 2 hydrochloride (example 1) inhibits histamine (HY-B1204)-induced gastric acid secretion in SD rats[1].
P-CAB agent 2 hydrochloride (600, 2000 mg/kg; p.o.; once) shows no acute toxicity and 600mg/kg shows no significant effect on animal body weight in SD rats[1]. | Animal Model: | 180-220 g, SPF grade, male SD rats[1] | | Dosage: | 2 mg/kg | | Administration: | P.o.; once | | Result: | Inhibited histamine-induced gastric acid secretion with the acid suppression rate of 55.4%. |
| [References]
[1] YinLin Qin, et al. Pyrrole sulfonyl derivative, and preparation method and medical use thereof. WO2016119505A1. |
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