| Chemical Properties | Back Directory | [Boiling point ]
1483.569±65.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.468±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [pka]
12.879±0.46(predicted) | [Sequence]
{Abz}-His-Pro-Gly-Gly-Pro-Gln-{EDDnp} |
| Hazard Information | Back Directory | [Uses]
Abz-HPGGPQ-EDDnp (Cathepsin K substrate) is a biological active peptide. (Cathepsins are a class of globular lysosomal proteases, playing a vital role in mammalian cellular turnover. They degrade polypeptides and are distinguished by their substrate specificities. Cathepsin K is the lysosomal cysteine protease involved in bone remodeling and resorption. It has potential as a drug target in autoimmune diseases and osteoporosis.This FRET peptide can be used to monitor selectively cathepsin K activity in physiological fluids and cell lysates. Abz-HPGGPQ-EDDnp [where Abz represents o-aminobenzoic acid and EDDnp represents N -(2, 4-dinitrophenyl)-ethylenediamine], a substrate initially developed for trypanosomal enzymes, is efficiently cleaved at the Gly-Gly bond by cathepsin K. This peptide is resistant to hydrolysis by cathepsins B, F, H, L, S and V, Ex/Em=340 nm/420 nm.) |
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