| Identification | Back Directory | [Name]
PF-06807656 | [CAS]
2213468-04-1 | [Synonyms]
PF-06807656
Benzamide, 3-[[(4-chlorophenyl)amino]sulfonyl]-4-methoxy-N-[1-(2-methyl-2H-1,2,3-triazol-4-yl)ethyl]- | [Molecular Formula]
C19H20ClN5O4S | [MOL File]
2213468-04-1.mol | [Molecular Weight]
449.91 |
| Chemical Properties | Back Directory | [density ]
1.43±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 2mg/mL, clear | [form ]
powder | [pka]
7.35±0.10(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Biological Activity]
PF-06807656 is a 3-sulfamoylbenzamide-based renal outer medullary potassium channel (ROMKCCNJ1Kir1.1) inhibitor (IC50 = 61 nM by whole cell patch clamp) th at is insensitive to K80M or N171D pore mutation and exhibits high selectivity for human over r at species (IC50 against thallium sulfate/TlSO4-stimulated influx = 391 nM vs. >30 μM using human or r at ROMK1-expressing HEK293 cells; 82% vs. 0% inhibition by patch clamp using human or r at ROMK2-expressing HEK293 cells). |
|
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
Biorbyt Ltd.
|
| Tel: |
+44 (0)1223 859 353 |
| Website: |
http://www.biorbyt.com |
|