| Identification | Back Directory | [Name]
IIIM-290
(IIIM290) | [CAS]
2213468-64-3 | [Synonyms]
IIIM-290
(IIIM290)
4H-1-Benzopyran-4-one, 2-[2-(2,6-dichlorophenyl)ethenyl]-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]- | [Molecular Formula]
C23H21Cl2NO5 | [MDL Number]
MFCD31813627 | [MOL File]
2213468-64-3.mol | [Molecular Weight]
462.32 |
| Hazard Information | Back Directory | [Uses]
IIIM-290 is a potent and oral CDK inhibitor with IC50s of 90 and 94 nM for CDK2/A and CDK9/T1. | [IC 50]
CDK2/A: 90 nM (IC50); CDK9/T1: 94 nM (IC50) | [References]
[1] Bharate SB, et al. Discovery and Preclinical Development of IIIM-290, an Orally Active Potent Cyclin-Dependent Kinase Inhibitor. J Med Chem. 2018 Feb 22;61(4):1664-1687. DOI:10.1021/acs.jmedchem.7b01765 |
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| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 13348960310; |
| Website: |
https://www.weikeqi-biotech.com/ |
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