| Identification | Back Directory | [Name]
Benzenedodecanoic acid, α,α,4-trichloro- | [CAS]
221564-97-2 | [Synonyms]
K111
K-111
K 111
BM170744
BM-170744
BM 170744
Benzenedodecanoic acid, α,α,4-trichloro-
2,2-Dichloro-12-(4-chlorophenyl)dodecanoic acid | [Molecular Formula]
C18H25Cl3O2 | [MOL File]
221564-97-2.mol | [Molecular Weight]
379.75 |
| Hazard Information | Back Directory | [Uses]
K-111 (BM-170744) is an oral active PPAR alpha agonist. K-111 show efficacy in improving insulin resistance, reducing body weight, and ameliorating atherogenic dyslipidemia. K-111 can be used for study of type 2 diabetes, dyslipidaemia, obesity and the metabolic syndrome[1][2]. | [References]
[1] Sch?fer SA, et al. Biochemical and morphological effects of K-111, a peroxisome proliferator-activated receptor (PPAR)alpha activator, in non-human primates. Biochem Pharmacol. 2004;68(2):239-251. DOI:10.1016/j.bcp.2004.03.004
[2] Ortmeyer HK, et al. Skeletal muscle glycogen synthase subcellular localization: effects of insulin and PPAR-alpha agonist (K-111) administration in rhesus monkeys. Am J Physiol Regul Integr Comp Physiol. 2005;288(6):R1509-R1517. DOI:10.1152/ajpregu.00692.2004 |
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