| Identification | Back Directory | [Name]
2-Propenoic acid, 3-[4'-hydroxy-2-[(hydroxyimino)methyl]-3'-tricyclo[3.3.1.13,7]dec-1-yl[1,1'-biphenyl]-4-yl]-, (2E)- | [CAS]
2217671-41-3 | [Synonyms]
POLA1 inhibitor 1
2-Propenoic acid, 3-[4'-hydroxy-2-[(hydroxyimino)methyl]-3'-tricyclo[3.3.1.13,7]dec-1-yl[1,1'-biphenyl]-4-yl]-, (2E)- | [Molecular Formula]
C26H27NO4 | [MOL File]
2217671-41-3.mol | [Molecular Weight]
417.5 |
| Chemical Properties | Back Directory | [Boiling point ]
643.1±55.0 °C(Predicted) | [density ]
1.35±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
-95.65±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
POLA1 inhibitor 1 (Compound 12) is an orally active POLA1 inhibitor. POLA1 inhibitor 1 shows antitumor activity against several tumor histotypes and Adarotene-resistant cell line[1]. | [in vivo]
POLA1 inhibitor 1 (Compound 12) (15 mg/kg and 50 mg/kg) displays a significantly antitumor effect in HT-29 and MM487 xenografts[1]. | [References]
[1] Cincinelli R, et al. Novel adamantyl retinoid-related molecules with POLA1 inhibitory activity. Bioorg Chem. 2020 Nov;104:104253. DOI:10.1016/j.bioorg.2020.104253 |
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