| Identification | Back Directory | [Name]
PPARγ agonist 16 | [CAS]
2218046-01-4 | [Synonyms]
PPARγ agonist 16
2,4-Thiazolidinedione, 3-[2-(4-bromophenyl)-2-oxoethyl]-5-[(2-methoxyphenyl)methylene]- | [Molecular Formula]
C19H14BrNO4S | [MOL File]
2218046-01-4.mol | [Molecular Weight]
432.29 |
| Chemical Properties | Back Directory | [Boiling point ]
591.071±60.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.559±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [pka]
-2.929±0.20(predicted) |
| Hazard Information | Back Directory | [Uses]
PPARγ agonist 16 (Compound 4G) is the agonist for PPARγ, that competitively binds to LBD domain of PPARγ with IC50 of 1790 nM. PPARγ agonist 16 inhibits the ear swelling in mouse model, and exhibits anti-hyperglycemic in Streptozotocin (HY-13753)-induced mouse diabetes mellitus model[1]. | [IC 50]
PPAR-γ: 1790 nM (IC50) | [References]
[1] Sun J, et al., Design, synthesis and bioactivity evaluation of thiazolidinedione derivatives as partial agonists targeting PPARγ. Bioorg Chem. 2021 Nov;116:105342. DOI:10.1016/j.bioorg.2021.105342 |
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