| Identification | Back Directory | [Name]
Cyclic di-GMP (sodium salt) | [CAS]
2222132-40-1 | [Synonyms]
Cyclic-di-GMP disodium
Cyclic di-GMP (sodium salt) | [Molecular Formula]
C20H25N10NaO14P2 | [MOL File]
2222132-40-1.mol | [Molecular Weight]
714.41 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -80°C, protect from light, stored under nitrogen | [solubility ]
Water: 1 mg/ml | [form ]
A crystalline solid | [color ]
Off-white to light yellow | [Water Solubility ]
Soluble to 20 mM in water |
| Hazard Information | Back Directory | [Description]
Cyclic di-GMP sodium is a second messenger in bacteria involved in diverse prokaryotic processes, including biofilm formation, motility, virulence, and cell cycling. | [Uses]
Cyclic-di-GMP disodium is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP disodium has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP disodium can be used in cancer research[1][2][3][4]. | [in vivo]
Cyclic-di-GMP disodium (100 μg/per; i.v.; two sequential vaccinations 9 days apart) enhances TriVax-induced immune responses to melanoma in mice and further increased the anti-tumor effects of TriVax[3]. | Animal Model: | C57BL/6 (B6) mice (8- to 10-week-old)[3]. | | Dosage: | 100 μg/per | | Administration: | Intravenous injection; two sequential vaccinations 9 days apart; combine with TriVax. | | Result: | Significantly higher numbers of antigen-specific CD8 T cells when combined with TriVax. (TriVax consisted of a mixture of 120 μg Pam-hgp100, 100 μg hgp100 or 100 μg Ova, 50 or 25 μg anti-CD40 antibody, and 25 μg Poly-IC).
Enhanced the anti-tumor activity of TriVax.
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| [storage]
Store at -20°C | [References]
[1] Karaolis DK, et al. 3',5'-Cyclic diguanylic acid (c-di-GMP) inhibits basal and growth factor-stimulated human colon cancer cell proliferation. Biochem Biophys Res Commun. 2005 Apr 1;329(1):40-5. DOI:10.1016/j.bbrc.2005.01.093
[2] Steinberger O, et al. Elevated expression of the CD4 receptor and cell cycle arrest are induced in Jurkat cells by treatment with the novel cyclic dinucleotide 3',5'-cyclic diguanylic acid. FEBS Lett. 1999 Feb 5;444(1):125-9. DOI:10.1016/s0014-5793(99)00036-8
[3] Wang Z, et al. STING activator c-di-GMP enhances the anti-tumor effects of peptide vaccines in melanoma-bearing mice. Cancer Immunol Immunother. 2015 Aug;64(8):1057-66. DOI:10.1007/s00262-015-1713-5
[4] Jenal U, et al. Cyclic di-GMP: second messenger extraordinaire. Nat Rev Microbiol. 2017 May;15(5):271-284. DOI:10.1038/nrmicro.2016.190 |
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