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2222280-83-1

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2222280-83-1 Structure

2222280-83-1 Structure
IdentificationBack Directory
[Name]

SHP504
[CAS]

2222280-83-1
[Synonyms]

SHP504
3-[4-(2-Chlorobenzyl)-5-oxo-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinazolin-1-yl]-4-hydroxybenzoic Acid
Benzoic acid, 3-[4-[(2-chlorophenyl)methyl]-4,5-dihydro-5-oxo[1,2,4]triazolo[4,3-a]quinazolin-1-yl]-4-hydroxy-
[Molecular Formula]

C23H15ClN4O4
[MOL File]

2222280-83-1.mol
[Molecular Weight]

446.84
Chemical PropertiesBack Directory
[Boiling point ]

796.2±70.0 °C(Predicted)
[density ]

1.54±0.1 g/cm3(Predicted)
[pka]

4.12±0.10(Predicted)
Hazard InformationBack Directory
[Uses]

SHP504 is a SHP2 phosphatase inhibitor, with an IC50 of 21 μM for SHP21–525[1].
[References]

[1] Michelle Fodor, et al. Dual Allosteric Inhibition of SHP2 Phosphatase. ACS Chem Biol. 2018 Mar 16;13(3):647-656. DOI:10.1021/acschembio.7b00980
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