| Identification | Back Directory | [Name]
SNIPER(ABL)-058 | [CAS]
2222354-61-0 | [Synonyms]
SNIPER(ABL)-058
Benzamide, 1-[[4-[2-[2-[2-[2-[3-[[2-[(2S)-1-[(2S)-2-cyclohexyl-2-[[(2S)-2-(methylamino)-1-oxopropyl]amino]acetyl]-2-pyrrolidinyl]-4-thiazolyl]carbonyl]phenoxy]ethoxy]ethoxy]ethoxy]acetyl]-1-piperazinyl]methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]- | [Molecular Formula]
C62H75N11O9S | [MDL Number]
MFCD32062722 | [MOL File]
2222354-61-0.mol | [Molecular Weight]
1150.41 |
| Hazard Information | Back Directory | [Uses]
SNIPER(ABL)-058, conjugating Imatinib (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 10 μM[1]. | [References]
[1] Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108(8):1657-1666. DOI:10.1111/cas.13284 |
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