| Identification | Back Directory | [Name]
SNIPER(ABL)-024 | [CAS]
2222355-77-1 | [Synonyms]
SNIPER(ABL)-024
Benzamide, N-[2-[2-[2-[2-[3-[[2-[(2S)-1-[(2S)-2-cyclohexyl-2-[[(2S)-2-(methylamino)-1-oxopropyl]amino]acetyl]-2-pyrrolidinyl]-4-thiazolyl]carbonyl]phenoxy]ethoxy]ethoxy]ethoxy]ethyl]-3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]- | [Molecular Formula]
C52H61F3N8O9S | [MDL Number]
MFCD32062724 | [MOL File]
2222355-77-1.mol | [Molecular Weight]
1031.15 |
| Hazard Information | Back Directory | [Uses]
SNIPER(ABL)-024, conjugating GNF5 (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 5μM[1]. | [References]
[1] Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108(8):1657-1666. DOI:10.1111/cas.13284 |
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