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2223014-57-9

2223014-57-9 Structure

2223014-57-9 Structure
IdentificationBack Directory
[Name]

Y08175
[CAS]

2223014-57-9
[Synonyms]

Y08175
[Molecular Formula]

C23H19FN4O5
[MOL File]

2223014-57-9.mol
[Molecular Weight]

450.42
Chemical PropertiesBack Directory
[Boiling point ]

610.9±55.0 °C(Predicted)
[density ]

1.42±0.1 g/cm3(Predicted)
[pka]

3.84±0.10(Predicted)
Hazard InformationBack Directory
[Description]

Y08175 is a CBP/P300 BRD inhibitor
[Uses]

Y08175 is a potent CBP bromodomain inhibitor. Y08175 exhibits considerable inhibitory effect with IC50s of 37 and 178.15 nM against CBP bromodomain in AlphaScreen assay and HTRF assay, respectively. Y08175 can be used for the research of prostate cancer[1].
[References]

[1] Xiang Q, et al. Design, Synthesis, and Biological Evaluation of 1-(Indolizin-3-yl)ethan-1-ones as CBP Bromodomain Inhibitors for the Treatment of Prostate Cancer. J Med Chem. 2022;65(1):785-810. DOI:10.1021/acs.jmedchem.1c01864
2223014-57-9 suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354 , +17819995354
Website:
Company Name: Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd  
Tel: 15317229551
Website: https://www.ureiko.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
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