| Identification | Back Directory | [Name]
7H-Pyrrolo[2,3-d]pyrimidine-5-carboximidicacid, 4-amino-7-b-D-ribofuranosyl-,hydrazide | [CAS]
22242-91-7 | [Synonyms]
SLM6
SLM-6
SLM 6
NSC 107517
NSC-107517
Sangivamycin-Like Molecule 6
7H-Pyrrolo[2,3-d]pyrimidine-5-carboximidicacid, 4-amino-7-b-D-ribofuranosyl-,hydrazide | [Molecular Formula]
C12H17N7O4 | [MOL File]
22242-91-7.mol | [Molecular Weight]
323.308 |
| Hazard Information | Back Directory | [Description]
SLM6 is an inhibitor of cyclin-dependent kinase-9 (CDK9). It exhibits potent anti-multiple myeloma activity. | [Uses]
SLM6 is a sangivamycin-like molecule. SLM6 is a CDK9 inhibitor. SLM6 inhibits CDK9/cyclin K and CDK9/cyclin T1 kinase activity with IC50s of 280 nM and 133 nM, respectively. SLM6 also inhibits CDK1/cyclin B and CDK2/
cyclin A with IC50s of less than 300 nM. SLM6 induces apoptosis in multiple myeloma (MM) cells[1]. | [IC 50]
CDK9/cyclinT1: 133 nM (IC50) | [References]
[1] Villanueva-Gutierrez EE, et al. Simple Sequence Repeat Markers Reveal Genetic Diversity and Population Structure of Bolivian Wild and Cultivated Tomatoes (Solanum lycopersicum L.). Genes (Basel). 2022 Aug 23;13(9):1505. DOI:10.3390/genes13091505 |
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