| Identification | Back Directory | [Name]
(6S)-5,10-Dihydro-2-methoxy-3-(3-methoxypropoxy)-6-(1-methylethyl)-10-oxo-6H-pyrido[1,2-h]-1,7-naphthyridine-9-carboxylic acid | [CAS]
2226178-35-2 | [Synonyms]
AB-452
(6S)-5,10-Dihydro-2-methoxy-3-(3-methoxypropoxy)-6-(1-methylethyl)-10-oxo-6H-pyrido[1,2-h]-1,7-naphthyridine-9-carboxylic acid | [Molecular Formula]
C21H26N2O6 | [MOL File]
2226178-35-2.mol | [Molecular Weight]
402.44 |
| Hazard Information | Back Directory | [Uses]
AB-452, a Dihydroquinolizinone (DHQ) analogue, is a potent and orally active HBV RNA destabilizer. AB-452 inhibits PAPD5/7 proteins in vitro with good in vivo efficacy in a chronic HBV mouse model[1]. | [References]
[1] Dimitar Gotchev, et al. Structure-Activity Relationships and Discovery of (S)-6-Isopropyl-2-methoxy-3-(3-methoxypropoxy)-10-oxo-5,10-dihydro-6H-pyrido[1,2-h][1,7]naphthyridine-9-carboxylic Acid (AB-452), a Novel Orally Available HBV RNA Destabilizer. J. Med. Chem. January 8, 2024. |
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