| Identification | Back Directory | [Name]
1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-(2-propyn-1-yloxy)- | [CAS]
2226303-74-6 | [Synonyms]
Thalidomide-5-propargyl
2-(2,6-dioxopiperidin-3-yl)-5-(prop-2-yn-1-yloxy)isoindoline-1,3-dione
1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-(2-propyn-1-yloxy)- | [Molecular Formula]
C16H12N2O5 | [MOL File]
2226303-74-6.mol | [Molecular Weight]
312.28 |
| Chemical Properties | Back Directory | [Boiling point ]
587.6±50.0 °C(Predicted) | [density ]
1.469±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C, stored under nitrogen | [form ]
Solid | [pka]
10.70±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Thalidomide-5-propargyl is a propargyl-modified Thalidomide (HY-14658), that acts as a Cereblon ligand to recruit CRBN proteins. Thalidomide-5-propargyl use alkynyl group at the end to be directly used in the synthesis of triazoles in the synthesis of PROTAC molecules, and is a key intermediate in the synthesis of PROTAC molecules based on CRBN design[1]. | [IC 50]
Cereblon | [References]
[1] Crew, et al. Preparation of tau-protein targeting bifunctional compounds (PROTACS) as E3 ubiquitin ligase binding useful in treatment and prevention of diseases. United States, US20180125821 A1. 2018-05-10. |
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