| Identification | Back Directory | [Name]
FM479 | [CAS]
2226521-64-6 | [Synonyms]
FM479
2-Propenamide, 2-cyano-3-[5-(1-cyclohexyl-1,6-dihydro-6-methylimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-2-furanyl]-N,N-dimethyl- | [Molecular Formula]
C25H26N6O2 | [MDL Number]
MFCD31697722 | [MOL File]
2226521-64-6.mol | [Molecular Weight]
442.51 |
| Chemical Properties | Back Directory | [Boiling point ]
735.7±70.0 °C(Predicted) | [density ]
1.33±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 2mg/mL, clear | [form ]
powder | [pka]
6.39±0.40(Predicted) | [color ]
yellow to orange | [InChI]
1S/C25H26N6O2/c1-29(2)25(32)16(14-26)13-18-9-10-21(33-18)24-28-20-15-27-23-19(11-12-30(23)3)22(20)31(24)17-7-5-4-6-8-17/h9-13,15,17H,4-8H2,1-3H3/b16-13+ | [InChIKey]
RPIGHLXKDWUGDT-DTQAZKPQSA-N | [SMILES]
CN(C(/C(C#N)=C/C(O1)=CC=C1C2=NC3=CN=C(N(C)C=C4)C4=C3N2C5CCCCC5)=O)C |
| Hazard Information | Back Directory | [Uses]
FM-479 is the negative control of FM-381 (HY-102046) and has no activity on JAK3 or other kinases[1]. FM-381 is a potent covalent reversible inhibitor of?JAK3?targeting the unique Cys909. FM-381 has an?IC50?of 127 pM for JAK3, with 410, 2700 and 3600-fold selectivity over JAK1, JAK2 and TYK2, respectively. | [Biological Activity]
FM-479 is a negative control for FM-381 (HY-102046) and has no activity against JAK3 or other kinases. FM-381 is a potent covalent reversible inhibitor of JAK3 targeting unique Cys909. | [in vitro]
FM-479 is the inactive control of FM-381, the concentration used in assays is similar. | [target]
| [IC 50]
JAK3 | [References]
[1] https://www.thesgc.org/chemical-probes/FM-381 |
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| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
|