| Identification | Back Directory | [Name]
Benzeneacetamide, N-[(3S,4S)-3,4-dihydro-4-(methylsulfonyl)-2H-1-benzopyran-3-yl]-4-fluoro-α-methyl-, (αS)- | [CAS]
2226732-62-1 | [Synonyms]
CVN636
Benzeneacetamide, N-[(3S,4S)-3,4-dihydro-4-(methylsulfonyl)-2H-1-benzopyran-3-yl]-4-fluoro-α-methyl-, (αS)- | [Molecular Formula]
C19H20FNO4S | [MOL File]
2226732-62-1.mol | [Molecular Weight]
377.43 |
| Chemical Properties | Back Directory | [Boiling point ]
629.6±55.0 °C(Predicted) | [density ]
1.33±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
13.48±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
CVN636 is a potent, orally active and selective mGluR7 allosteric agonist with an EC50 value of 7 nM for hu mGluR7. CVN636 has central nervous system (CNS) permeability[1]. | [in vivo]
CVN636 (0.3-3 mg/kg; p.o.) reduces ethanol self-administration in msP rats[1]. | Animal Model: | msP rat[1] | | Dosage: | 0.3, 1, and 3 mg/kg | | Administration: | oral administration | | Result: | Reduced alcohol self-administration in a dose-dependent. |
| [IC 50]
hu mGluR7: 7 nM (EC50) | [References]
[1] Ayscough AP, et, al. Discovery of CVN636: A Highly Potent, Selective, and CNS Penetrant mGluR7 Allosteric Agonist. ACS Med Chem Lett. 2023 Mar 2;14(4):442-449. DOI:10.1021/acsmedchemlett.2c00529
[2] Dickson L, et, al. Discovery of CVN636: A Highly Potent, Selective, and CNS Penetrant mGluR7 Allosteric Agonist. ACS Med Chem Lett. 2023 Mar 2;14(4):442-449. DOI:10.1021/acsmedchemlett.2c00529 |
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Biorbyt Ltd.
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+44 (0)1223 859 353 |
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http://www.biorbyt.com |
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