| Identification | Back Directory | [Name]
1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 1-(1,1-dimethylethyl)-3-(1H-indol-3-yl)- | [CAS]
2227110-54-3 | [Synonyms]
1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 1-(1,1-dimethylethyl)-3-(1H-indol-3-yl)- | [Molecular Formula]
C17H18N6 | [MOL File]
2227110-54-3.mol | [Molecular Weight]
306.36 |
| Chemical Properties | Back Directory | [Boiling point ]
583.6±50.0 °C(Predicted) | [density ]
1.38±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
15.13±0.30(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
3-IN-PP1 is a protein kinase D (PKD) inhibitor. 3-IN-PP1 has potent pan-PKD inhibitory activity for PKD1, PKD2 and PKD3 with IC50 values of 108, 94 and 108 nM, respectively. 3-IN-PP1 also is a broad spectrum anticancer agent and has inhibition of several tumor cells growth. 3-IN-PP1 can be used for the research of cancer[1]. | [IC 50]
PKD1: 108 nM (IC50); Cellular PKD2: 94 nM (IC50); PKD3: 108 nM (IC50) | [References]
[1] Philippe Gilles, et al. Design, synthesis and biological evaluation of pyrazolo[3,4-d]pyrimidine-based protein kinase D inhibitors. Eur J Med Chem DOI:10.1016/j.ejmech.2020.112638 |
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