| Identification | Back Directory | [Name]
DS18561882 | [CAS]
2227149-22-4 | [Synonyms]
DS18561882
Methanesulfonamide, N-[4-[[8-[(3S)-3,4-dimethyl-1-piperazinyl]-1,5-dihydro-7-methyl-5-oxo-2H-[1]benzopyrano[3,4-c]pyridin-3(4H)-yl]carbonyl]-2-(trifluoromethoxy)phenyl]- | [Molecular Formula]
C28H31F3N4O6S | [MDL Number]
MFCD32263053 | [MOL File]
2227149-22-4.mol | [Molecular Weight]
608.63 |
| Chemical Properties | Back Directory | [Boiling point ]
754.3±70.0 °C(Predicted) | [density ]
1.47±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 250 mg/mL (410.76 mM) | [form ]
Solid | [pka]
6.61±0.10(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Description]
DS18561882 is an isozyme-selective MTHFD2 inhibitor. DS18561882 shows a good oral pharmacokinetic profile, and thereby tumor growth inhibition in a mouse xenograft model upon oral administration. |
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