| Identification | Back Directory | [Name]
ZL0420 | [CAS]
2229039-45-4 | [Synonyms]
ZL0420
CS-2832
ZL 0420;ZL-0420
ZL 0420 ;ZL0420 ;ZL-0420
2(1H)-Quinolinone, 6-[2-(2-amino-4-hydroxy-5-methylphenyl)diazenyl]-3,4-dihydro- | [Molecular Formula]
C16H16N4O2 | [MOL File]
2229039-45-4.mol | [Molecular Weight]
296.32 |
| Chemical Properties | Back Directory | [Boiling point ]
645.9±55.0 °C(Predicted) | [density ]
1.41±0.1 g/cm3(Predicted) | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:9): 0.1 mg/ml | [form ]
A crystalline solid | [pka]
9.20±0.40(Predicted) |
| Hazard Information | Back Directory | [Description]
ZL0420 is a potent and selective BRD4 inhibitor. ZL0420 reduces airway inflammation and inhibits the TLR3-dependent innate immune gene program, including ISG54, ISG56, IL-8, and Groβ genes in cultured human small airway epithelial cells (hSAECs). | [Uses]
(E/Z)-ZL0420 is a racemic compound of (Z)-ZL0420 and (E)-ZL0420 isomers. (E)-ZL0420 is a potent and selective bromodomain-containing protein 4 (BRD4) inhibitor with IC50 values of 27 nM against BRD4 BD1 and 32 nM against BRD4 BD2[1]. | [References]
[1] Zhiqing Liu, et al. Discovery of potent and selective BRD4 inhibitors capable of blocking TLR3-induced acute airway inflammation. Eur J Med Chem. 2018 May 10;151:450-461. DOI:10.1016/j.ejmech.2018.04.006 |
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| Company Name: |
BOC Sciences
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| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
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