| Identification | Back Directory | [Name]
MFN2 agonist B-A l | [CAS]
2230047-87-5 | [Synonyms]
MFN2 agonist-1
MFN2 agonist B-A l
Urea, N-[2-[(5-cyclopropyl-4-phenyl-4H-1,2,4-triazol-3-yl)thio]ethyl]-N'-(2-methylcyclohexyl)- | [Molecular Formula]
C21H29N5OS | [MDL Number]
MFCD32174349 | [MOL File]
2230047-87-5.mol | [Molecular Weight]
399.55 |
| Hazard Information | Back Directory | [Uses]
MFN2 agonist-1 (B-A/l) potently stimulates mitochondrial fusion in mitofusin 2 (MFN2)-deficient cells. MFN2 agonist-1 reverses mitochondrial “clumping” (formation of static mitochondrial aggregates) and restores mitochondrial motility in cultured mouse neurons expressing the CMT2A mutant MFN2 T105M. | [References]
[1] Rocha AG, et al. MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A. Science. 2018 Apr 20;360(6386):336-341. DOI:10.1126/science.aao1785 |
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Biorbyt Ltd.
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+44 (0)1223 859 353 |
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http://www.biorbyt.com |
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