ChemicalBook--->CAS DataBase List--->2230051-33-7

2230051-33-7

2230051-33-7 Structure

2230051-33-7 Structure
IdentificationBack Directory
[Name]

Tyramide alkyne
[CAS]

2230051-33-7
[Synonyms]

Tyramide alkyne
[Molecular Formula]

C14H17NO2
[MOL File]

2230051-33-7.mol
[Molecular Weight]

231.29
Chemical PropertiesBack Directory
[Boiling point ]

469.978±35.00 °C(Press: 760.00 Torr)(predicted)
[density ]

1.104±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
[storage temp. ]

-10 to -25°C
[solubility ]

DMSO: 2mg/mL, clear
[form ]

Solid-Liquid Mixture
[pka]

10.009±0.15(predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

Tyramide alkyne is an alternative labeling substrate that can be coupled to detection or enrichment moieties via a Copper-catalyzed Azide/Alkyne Cycloaddition (CuAAC) “click” reaction. Tyramide alkyne can be used for ascorbate peroxidase 2 (APEX2) labeling[1].
[Biological Activity]

Tyramide alkyne (Alkyne-phenol 1) is a cell penetrant and highly efficient clickable ascorbate peroxidase 2 (APEX2) substrate th at significantly improves APEX-labeling efficiency in intact yeast cells. Tyramide alkyne enable biotin-independent detection of labeled proteins.
[References]

[1] Ganapathy US, et al. Compartment-Specific Labeling of Bacterial Periplasmic Proteins by Peroxidase-Mediated Biotinylation. ACS Infect Dis. 2018 Jun 8;4(6):918-925. DOI:10.1021/acsinfecdis.8b00044
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