| Identification | Back Directory | [Name]
PKCiota-IN-49 | [CAS]
2230055-52-2 | [Synonyms]
PKCiota-IN-2
PKCiota-IN-49
PKCiota-IN-2, 10 mM in DMSO
6-methoxy-7-(5-{1H-pyrrolo[2,3-b]pyridin-4-yl}pyrazolo[1,5-a]pyridin-3-yl)-1,2,3,4-tetrahydroisoquinoline
Isoquinoline, 1,2,3,4-tetrahydro-6-methoxy-7-[5-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrazolo[1,5-a]pyridin-3-yl]- | [Molecular Formula]
C24H21N5O | [MOL File]
2230055-52-2.mol | [Molecular Weight]
395.46 |
| Hazard Information | Back Directory | [Uses]
PKCiota-IN-2 (Compound 49) is a potent PKCiota (PKC-ι) inhibitor with an IC50 of 2.8 nM. PKCiota-IN-2 also inhibits PKC-α and PKC-ε with IC50s of 71 nM and 350 nM, respectively[1]. | [IC 50]
PKCι: 2.8 nM (IC50); PKCα: 71 nM (IC50); PKCε: 350 nM (IC50) | [References]
[1] Jacek Kwiatkowski, et al. Fragment-Based Drug Discovery of Potent Protein Kinase C Iota Inhibitors. J Med Chem. 2018 May 24;61(10):4386-4396. DOI:10.1021/acs.jmedchem.8b00060 |
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