| Identification | Back Directory | [Name]
ZL0420 | [CAS]
2230496-80-5 | [Synonyms]
2(1H)-Quinolinone, 6-[(1E)-2-(2-amino-4-hydroxy-5-methylphenyl)diazenyl]-3,4-dihydro- | [Molecular Formula]
C16H16N4O2 | [MDL Number]
MFCD31807601 | [MOL File]
2230496-80-5.mol | [Molecular Weight]
296.32 |
| Chemical Properties | Back Directory | [Boiling point ]
645.9±55.0 °C(Predicted) | [density ]
1.41±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:9): 0.1 mg/ml | [form ]
Solid | [pka]
9.56±0.36(Predicted) | [color ]
Yellow to orange |
| Hazard Information | Back Directory | [Uses]
ZL0420 is a potent and selective bromodomain-containing protein 4 (BRD4) inhibitor with IC50 values of 27 nM against BRD4 BD1 and 32 nM against BRD4 BD2. | [in vivo]
ZL0420 demonstrates potent efficacy reducing airway inflammation in a mouse model with low toxicity. ZL0420 displays high efficacy and almost completely blocks the profound accumulation of neutrophils around the small and medium sized airways induced by poly(I:C) administration[1]. | [storage]
Store at -20°C | [References]
[1] Liu Z, et al. Discovery of potent and selective BRD4 inhibitors capable of blocking TLR3-induced acute airway inflammation. Eur J Med Chem. 2018 May 10;151:450-461. DOI:10.1016/j.ejmech.2018.04.006 |
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