| Identification | Back Directory | [Name]
INDEX NAME NOT YET ASSIGNED | [CAS]
2230826-33-0 | [Synonyms]
(R,S,S)-VH032
(4S)-3-Methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-D-prolinamide
(4S)-3-Methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-D-prolinamide HCl | [Molecular Formula]
C22H30N4O3S | [MOL File]
2230826-33-0.mol | [Molecular Weight]
430.57 |
| Chemical Properties | Back Directory | [Boiling point ]
691.6±55.0 °C(Predicted) | [density ]
1.254±0.06 g/cm3(Predicted) | [storage temp. ]
Storage temp. 2-8°C | [form ]
Solid | [pka]
14.10±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
(R,S,S)-VH032 is Ligand for E3 Ligase used in the synthesis of PROTACs. VH032 is a VHL ligand and VHL/HIF-1α interaction inhibitor that recruits von Hippel-Lindau (VHL) proteins. (R,S,S)-VH032 synthesizes the tau-targeting small molecule PROTAC C004019 (HY-138669)[1]. | [IC 50]
VHL | [References]
[1] Wang W, et al. A novel small-molecule PROTAC selectively promotes tau clearance to improve cognitive functions in Alzheimer-like models. Theranostics. 2021 Mar 11;11(11):5279-5295. DOI:10.7150/thno.55680 |
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