| Identification | Back Directory | [Name]
Pentanediamide, N1-[4-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]butyl]-N5-[19-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-15-oxo-4,7,10-trioxa-14-azanonadec-1-yl]- | [CAS]
2230857-87-9 | [Synonyms]
Biotin-Thalidomide
Pentanediamide, N1-[4-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]butyl]-N5-[19-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-15-oxo-4,7,10-trioxa-14-azanonadec-1-yl]- | [Molecular Formula]
C44H64N8O13S | [MOL File]
2230857-87-9.mol | [Molecular Weight]
945.09 |
| Chemical Properties | Back Directory | [Boiling point ]
1257.5±65.0 °C(Predicted) | [density ]
1.280±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [form ]
Solid | [pka]
10.68±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Biotin-Thalidomide is a cereblon affinity probe for PROTAC and targeted protein degradation research. | [IC 50]
Cereblon | [References]
[1] Nabet B, et al. The dTAG system for immediate and target-specific protein degradation. Nat Chem Biol. 2018 May;14(5):431-441. DOI:10.1038/s41589-018-0021-8 |
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| Company Name: |
Merck KGaA
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21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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