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2231089-95-3

2231089-95-3 Structure

2231089-95-3 Structure
IdentificationBack Directory
[Name]

DS-88790512)
[CAS]

2231089-95-3
[Synonyms]

DS-88790512)
DS88790512 (DS 88790512
DS88790512 hydrochloride (DS 88790512
[Molecular Formula]

C22H29N3O2
[MDL Number]

MFCD31813668
[MOL File]

2231089-95-3.mol
[Molecular Weight]

367.48
Chemical PropertiesBack Directory
[Boiling point ]

540.6±50.0 °C(Predicted)
[density ]

1.20±0.1 g/cm3(Predicted)
[pka]

10.98±0.20(Predicted)
Hazard InformationBack Directory
[Uses]

DS88790512 is a potent, selective, and orally bioavailable TRPC6 inhibitor with an IC50 of 11 nM.
[References]

[1] Motoyama K, et al. Discovery of a bicyclo[4.3.0]nonane derivative DS88790512 as a potent, selective, and orally bioavailable blocker of transient receptor potential canonical 6 (TRPC6). Bioorg Med Chem Lett. 2018 Jul 1;28(12):2222-2227. DOI:10.1016/j.bmcl.2018.03.056
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