| Identification | Back Directory | [Name]
1H-Imidazole, 5-[(1S,2S)-2-(5,5-dimethyl-1-hexyn-1-yl)cyclopropyl]- | [CAS]
223420-11-9 | [Synonyms]
Cipralisant (enantiomer)
1H-Imidazole, 5-[(1S,2S)-2-(5,5-dimethyl-1-hexyn-1-yl)cyclopropyl]- | [Molecular Formula]
C14H20N2 | [MOL File]
223420-11-9.mol | [Molecular Weight]
216.32 |
| Chemical Properties | Back Directory | [Boiling point ]
386.7±31.0 °C(Predicted) | [density ]
1.03±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
14.18±0.10(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
Cipralisant (GT-2331) enantiomer is the enantiomer of Cipralisant (HY-106993), Cipralisant is an orally active, potent, selective, and high affinity histamine H3 receptor antagonist (rat Ki=0.47 nM)[1][2][3][4][5]. Cipralisant (enantiomer) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [References]
[1] Liu H, et al. An efficient multigram synthesis of the potent histamine H3 antagonist GT-2331 and the reassessment of the absolute configuration. J Org Chem. 2004 Jan 9;69(1):192-4. DOI:10.1021/jo035264t
[2] Raddatz R, et al. Histamine H3 antagonists for treatment of cognitive deficits in CNS diseases. Curr Top Med Chem. 2010;10(2):153-69. DOI:10.2174/156802610790411027
[3] Fox GB, et al. Effects of histamine H(3) receptor ligands GT-2331 and ciproxifan in a repeated acquisition avoidance response in the spontaneously hypertensive rat pup. Behav Brain Res. 2002 Apr 1;131(1-2):151-61. DOI:10.1016/s0166-4328(01)00379-5
[4] Ito S, et al. Detailed pharmacological characterization of GT-2331 for the rat histamine H3 receptor. Eur J Pharmacol. 2006 Jan 4;529(1-3):40-6. DOI:10.1016/j.ejphar.2005.10.066
[5] Tedford CE, et al. High antagonist potency of GT-2227 and GT-2331, new histamine H3 receptor antagonists, in two functional models. Eur J Pharmacol. 1998 Jun 26;351(3):307-11. DOI:10.1016/s0014-2999(98)00396-3 |
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