| Identification | Back Directory | [Name]
JI-130) | [CAS]
2234271-86-2 | [Synonyms]
JI-130)
JI130
(JI 130
2-Propenamide, 3-(7-methoxy-1H-indol-3-yl)-N-[2-[2-(2-propen-1-yloxy)phenyl]ethyl]-, (2E)- | [Molecular Formula]
C23H24N2O3 | [MOL File]
2234271-86-2.mol | [Molecular Weight]
376.45 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
DMSO: 2mg/mL, clear | [form ]
Solid | [color ]
White to light yellow | [InChI]
1S/C23H24N2O3/c1-3-15-28-20-9-5-4-7-17(20)13-14-24-22(26)12-11-18-16-25-23-19(18)8-6-10-21(23)27-2/h3-12,16,25H,1,13-15H2,2H3,(H,24,26)/b12-11+ | [InChIKey]
BNTYDBBGNPFECO-VAWYXSNFSA-N | [SMILES]
O=C(/C=C/C1=CNC2=C1C=CC=C2OC)NCCC3=CC=CC=C3OCC=C |
| Hazard Information | Back Directory | [Description]
JI130 is an inhibitor of the cancer-associated transcription factor Hes1 via the PHB2 chaperone. JI130 stabilizes PHB2's interaction with Hes1 outside the nucleus, inducing G2/M cell cycle arrest. | [Uses]
JI130 (JI051 derivative?) is a stabilizer for the?Hes1-PHB2?interaction. JI130 inhibits?the ability of Hes1 to repress transcription. JI130?significantly reduces the tumor growth in a murine pancreatic tumor model and has the potential for ?managing pancreatic cancer[1]. | [References]
[1] Amelie Perron, et al. Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone. J Biol Chem. 2018 May 25;293(21):8285-8294. DOI:10.1074/jbc.RA118.002316 |
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| Company Name: |
Merck KGaA
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| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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