| Identification | Back Directory | [Name]
JI051 | [CAS]
2234281-75-3 | [Synonyms]
JI051
JI051
(JI 051
JI051;JI 051;JI-051
2-Propenamide, N-[2-(2-ethoxyphenyl)ethyl]-3-(7-methoxy-1H-indol-3-yl)-, (2E)- | [Molecular Formula]
C22H24N2O3 | [MOL File]
2234281-75-3.mol | [Molecular Weight]
364.44 |
| Chemical Properties | Back Directory | [Boiling point ]
635.6±55.0 °C(Predicted) | [density ]
1.187±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:125.0(Max Conc. mg/mL);342.99(Max Conc. mM) | [form ]
Solid | [pka]
14.34±0.46(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
JI051 is a stabilizer for the Hes1-PHB2 interaction. JI051 interacts with a cancer-associated protein chaperone prohibitin 2 (PHB2), induces cell-cycle arrest by inhibiting the Notch downstream effector gene Hes1. Anti-cancer activity[1]. | [References]
[1] Perron A, et al. Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone. J Biol Chem. 2018 May 25;293(21):8285-8294. DOI:10.1074/jbc.RA118.002316 |
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| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
|