| Chemical Properties | Back Directory | [Boiling point ]
733.1±70.0 °C(Predicted) | [density ]
1.67±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
6.87±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
SHP389 is an allosteric SHP2 Inhibitor with (SHP2 IC50 - 36 nM). SHP389 modulates MAPK signaling in vivo.SHP389 improved SHP2 biochemical and cellular potency in trend with increasing lipophilicity. | [Uses]
SHP389 is an allosteric SHP2 inhibitor, with an IC50 of 36 nM for both SHP2 and p-ERK[1]. | [in vivo]
SHP389 modulates MAPK signaling in vivo[1]. |
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