| Identification | Back Directory | [Name]
Tubulin inhibitor 1 | [CAS]
2237054-53-2 | [Synonyms]
Tubulin inhibitor 1
1H-Pyrazole, 4-(4-ethoxyphenyl)-1-methyl-3-(3,4,5-trimethoxyphenyl)- | [Molecular Formula]
C21H24N2O4 | [MOL File]
2237054-53-2.mol | [Molecular Weight]
368.43 |
| Chemical Properties | Back Directory | [Boiling point ]
471.5±45.0 °C(Predicted) | [density ]
1.14±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 125 mg/mL (339.28 mM) | [form ]
Solid | [pka]
1.25±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Tubulin inhibitor 1 is a tubulin inhibitor, inhibits tubulin polymerization. Tubulin inhibitor 1 shows potent anti-tumor activity, casues cellular mitotic arrest in the G2/M phase, and induces cellular apoptosis[1]. | [in vivo]
Tubulin inhibitor 1 (50 mg/kg, i.p., every two days three times for 20-25 days) is well tolerated, significantly reduces tumour growth in Balb/c nude mice bearing SK-OV-3 cells[1]. | Animal Model: | Six-week-old Balb/c nude mice (18-20 g) beraring SK-OV-3 cells[1] | | Dosage: | 50 mg/kg | | Administration: | I.P., every two days three times for 20-25 days | | Result: | Significantly reduced tumour growth in Balb/c nude mice bearing SK-OV-3 cells, without obvious body weight loss. |
| [References]
[1] Lai Q, et al. Design, synthesis and biological evaluation of a novel tubulin inhibitor 7a3. Eur J Med Chem. 2018 Aug 5;156:162-179. DOI:10.1016/j.ejmech.2018.05.010 |
|
| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 13348960310; |
| Website: |
https://www.weikeqi-biotech.com/ |
|